After the sudden collapse of her family, Mim Malone is dragged from her home in northern Ohio to the "wastelands" of Mississippi, where she lives in a medicated milieu with her dad and new stepmom. Before the dust has a chance to settle, she learns her mother is sick back in Cleveland. So she ditches her new life and hops aboard a northbound Greyhound bus to her real home and her real mother, meeting a quirky cast of fellow travelers along the way....