Imprisoned vampire Barnabas Collins is inadvertently freed from his tomb and emerges into the very changed world of 1972. He returns to Collinwood Manor to find that his once-grand estate has fallen into ruin. The dysfunctional remnants of the Collins family have fared little better and are in need of his protection.

The continuing adventures of vampire roommates Nandor, Nadja, Laszlo and Colin Robinson and their human familiar Guillermo as they further explore the human world of Staten Island, New York.

Three vampires have lived together for hundreds of years. After an unexpected visit from their dark lord and leader, they're reminded that they were initially tasked with completing domination of the New World upon their arrival in Staten Island; over a hundred years ago. But what exactly is the best way to go about achieving said domination?

A young teen thinks his town of Santa Cruz is infested with vampires, and becomes convinced of it when his own brother starts turning into one.