A series of letters relating what happens when, after her father loses his job, Lydia Grace goes to live with her Uncle Jim in the city but takes her love for gardening with her.

"Inheriting your uncle's supervillain business is more complicated than you might think. Particularly when you discover who's running the place. Charlie's life is going nowhere fast. A divorced substitute teacher living with his cat in a house his siblings want to sell, all he wants is to open a pub downtown, if only the bank will approve his loan. Then his long-lost uncle Jake dies and leaves his supervillain business (complete with island volcano...

Pig Pig is concerned about travelling across the country with his aunt and uncle, but is even more worried when he returns.

After tragic events tear Mickey Bolitar away from his parents, he is forced to live with his estranged Uncle Myron and switch high schools, where he finds both friends and enemies, but when his new new girlfriend, Ashley, vanishes, he follows her trail into a seedy underworld that reveals she is not what she seems to be.

Kitty's owners are taking a week off and leaving Kitty and Puppy at home with Uncle Murray. It isn't long before Uncle Murray is driven to near madness by shenanigans of epic proportions.

When David goes out on his sailboat to scatter his recently deceased uncle's ashes to the wind, he is caught in a fierce storm and must survive many days on his own as he works out his feelings about life and his uncle.

When Peter goes on an African adventure with his beloved Uncle Nigel, who hopes to spot a rare gorilla, the oblivious Nigel urges Peter on by telling him to have gumption, while Peter keeps his eyes open and uses his ingenuity.

"Rancid rat hairs! I'd been spending so much money lately, I had none left in the bank! Even worse, when my grandfather found out, he sent me off to Moldy Manor. There, miserly Uncle Stingysnout would teach me to be better at saving. How terrible! Could I learn to be less wasteful without going crazy?"--

Heading to Penny Pincher Castle to visit his uncle for what he thinks will be a nice vacation, Geronimo is instead put to work.

Kate's humdrum life is transformed when her eccentric Uncle Herbert brings her a colossal locomotive train, the Silver Arrow, as her eleventh birthday gift, leading her and her younger brother on a mysterious quest.